View source for JZL184

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|ImageFile=jzl184_2structures.png
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|IUPACName=4-nitrophenyl-4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate
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|Section2= {{Chembox Properties
|  Formula=C<sub>27</sub>H<sub>24</sub>N<sub>2</sub>O<sub>9</sub>
|  MolarMass=520.15 g/mol
|  Appearance=Pale yellow solid
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'''JZL184''' is an irreversible [[enzyme inhibitor|inhibitor]] for [[monoacylglycerol lipase]] (MAGL), the primary [[enzyme]] responsible for degrading the [[endocannabinoid]] [[2-arachidonoylglycerol]] (2-AG).<ref name="pmid19029917">{{cite journal | author = Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF | title = Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | journal = Nat. Chem. Biol. | volume = 5| issue = 1| pages = 37–44| year = 2008 | month = November | pmid = 19029917 | doi = 10.1038/nchembio.129 | url = | pmc = 2605181  }}</ref> It displays high selectivity for MAGL over other [[brain]] [[serine hydrolase]]s, including the [[anandamide]]-degrading enzyme [[fatty acid amide hydrolase]] (FAAH), thereby making it a useful tool for studying the effects of endogenous [[2-AG]] signaling, ''in vivo''.  Administration of JZL184 to mice was reported to cause dramatic elevation of brain [[2-AG]] leading to several [[tetrad test|cannabinoid-related behavioral effects]].

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{{Cannabinoids}}



[[Category:Cannabinoids]]
[[Category:Benzodioxoles]]
[[Category:Alcohols]]
[[Category:Piperidines]]
[[Category:Carbamates]]
[[Category:Nitro compounds]]


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[[Category:2Fix]]