View source for 1-Iodomorphine

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| OtherNames = (5α,6α)-7,8-Didehydro-4,5-epoxy-1-iodo-17-methyl-morphinan-3,6-diol
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|  CASNo = 64739-76-0
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|  C=17|H=18|I=1|N=1|O=3
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'''1-Iodomorphine''' is a semi-synthetic narcotic analgesic formed by halogenation of the 1 position on the [[morphine]] carbon skeleton.<ref>{{Cite doi|10.1021/jo00398a049}}</ref><ref>{{Cite doi|10.1002/(SICI)1099-1344(1998090)41:9<811::AID-JLCR132>3.0.CO;2-3}}</ref><ref>{{Cite doi|10.1021/jm000119i}}</ref>  Halogenated morphine derivatives were first synthesised in Germany, Austria/Austria-Hungary, the United Kingdom and the United States in the period 1890 to 1930.  Use of this drug increased after 1945 for the below-mentioned research.  It is a [[research chemical]] which is often prepared in the laboratory when it is needed.

Along with the similar [[2-iodomorphine]] as well as iodinated analogs of [[dihydromorphine]], [[dihydrocodeine]], [[heroin]], and the fluorinated, chlorinated, and brominated analogues of this series, this change may not impact the activity of the drug to a notable extent{{Citation needed|date=August 2010}} but 1- and 2-iodomorphine are used in pharmacological, neurological, metabolic, and endocrine research as it allows the tagging of morphine with [[iodine-131]] or [[iodine-129]].<ref>{{Cite doi|10.1016/0883-2897(89)90064-0}}</ref>  Such research was important in the discovery of [[opioid receptors]] in the central nervous system, peripheral nervous system, and other tissues in humans, mammals, birds, and some reptiles, amphibians, fish, insects, and arthropods.

More recently, research on fluoro-opioids has showed that this subcategory of the semi-synthetic opioids may be a promising direction for research for strong opioids with very rapid onset of action.{{Citation needed|date=August 2010}}

==References==
{{Reflist}}

{{opioids}}

{{DEFAULTSORT:Iodomorphine, 1-}}
[[Category:Analgesics]]
[[Category:Morphinans]]
[[Category:Organoiodides]]
[[Category:2Fix]]