View source for Afimoxifene

{{chembox
|ImageFile= Afimoxifene.png
|ImageSize=
|IUPACName=(''Z'')-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
|OtherNames=4-hydroxytamoxifen
|Section1= {{Chembox Identifiers
|  CASNo=68392-35-8
|  PubChem=449459
|  SMILES=CC\C(c1ccccc1)=C(c2ccc(OCCN(C)C)cc2)/c3ccc(O)cc3
  }}
|Section2= {{Chembox Properties
|  Formula=C<sub>26</sub>H<sub>29</sub>NO<sub>2</sub>
|  MolarMass=387.51396
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
  }}
|Section3= {{Chembox Hazards
|  MainHazards=
|  FlashPt=
|  Autoignition=
  }}
}}
'''Afimoxifene'''<ref name="AMA_USAN">{{cite web | url = http://www.ama-assn.org/ama1/pub/upload/mm/365/afimoxifene.pdf | title = Statement on a nonproprietary name adopted by the USAN council: Afimoxifene | accessdate = 2008-03-26 | author = | authorlink = | coauthors = | date = | format = | work = | publisher = American Medical Association | pages = | language = | archiveurl = | archivedate = | quote = }}</ref> is a [[selective estrogen receptor modulator]] whose active ingredient is  '''4-hydroxytamoxifen''' which is identical to the active [[metabolite]] of [[tamoxifen]].<ref name="Desta_2004">{{cite journal |author=Desta Z, Ward BA, Soukhova NV, Flockhart DA|title=Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6|journal= J Pharmacol Exp Ther |volume= 310 |issue= 3 |pages= 1062–75 |year= 2004 | doi = 10.1124/jpet.104.065607 |pmid= 15159443}}</ref>  Afimoxifene is a transdermal  gel [[pharmaceutical formulation|formulation]] and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel.<ref name="AMA_USAN"/> Afimoxifene has completed a [[clinical_trial#Phase_II|phase II clinical trial]] for the treatment of cyclical [[mastalgia]].<ref name="pmid17351746">{{cite journal | author = Mansel R, Goyal A, Nestour EL, Masini-Etévé V, O'Connell K | title = A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women | journal = Breast Cancer Res. Treat. | volume = 106 | issue = 3 | pages = 389–97 | year = 2007 | pmid = 17351746 | doi = 10.1007/s10549-007-9507-x }}</ref>

== References ==
{{Reflist}}

== External links ==
*{{MeshName|4-hydroxytamoxifen}}

{{Sex hormones}}

[[Category:Selective estrogen receptor modulators]]
[[Category:Phenols]]
[[Category:Phenol ethers]]


{{pharma-stub}}
[[Category:2Fix]]