View source for Ajulemic acid

{{Drugbox|
|IUPAC_name = (6aR,10aR)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-Dibenzo(b,d)pyran-9-carboxylic acid
| image = Ajulemicacid.png
| width= 200
| CAS_number= 137945-48-3
| ATC_prefix= none
| ATC_suffix=
| PubChem= 3083542
| DrugBank=
| C=25 | H=36 | O=4
| molecular_weight = 400.551 g/mol
| bioavailability=
| metabolism = 
| elimination_half-life= 
| excretion = 
| pregnancy_category =
| legal_status = 
| routes_of_administration= 
}}

'''Ajulemic acid''' (AB-III-56, HU-239, IP-751) is a [[Chemical synthesis|synthetic]] [[cannabinoid]] derivative of the non-psychoactive [[Tetrahydrocannabinol|THC]] [[metabolite]] [[Tetrahydrocannabinol#Metabolism|11-nor-9-carboxy-THC]] which shows useful [[analgesic]] and [[anti-inflammatory]] effects without causing a subjective "high".<ref name="pmid15240185">{{Cite pmid|15240185}}</ref> It is being developed for the treatment of [[neuropathic]] pain and inflammatory conditions such as [[arthritis]].<ref name="pmid15925096">{{Cite pmid|15925096}}</ref> It does not however share the [[anti-emetic]] effects of other cannabinoids but may be useful for treating pain and chronic inflammatory conditions where nausea is not present.<ref name="pmid16146336">{{Cite pmid|16146336}}</ref> Side effects include dry mouth, tiredness and dizziness. The mechanism of action has not yet been established, but ajulemic acid may activate the [[CB1 receptor|CB<sub>1</sub> receptor]] in a different way to psychoactive cannabinoids. Studies in animals at 100x the dose used in human trials suggest that there is some psychoactivity of ajulemic acid, comparable to that produced by [[tetrahydrocannabinol]],<ref>{{Cite pmid|17105826}}</ref> however there was no difference between ajulemic acid and placebo on the "cannabimimetic" assay when used in humans at therapeutic doses.<ref>{{Cite pmid|15022343}}</ref><ref>{{Cite doi|10.1002/art.20806}}</ref>

== References ==
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{{Cannabinoids}}


[[Category:Cannabinoids]]
[[Category:Benzochromenes]]
[[Category:Carboxylic acids]]
[[Category:Phenols]]

[[it:Acido ajulemico]]
[[Category:2Fix]]