View source for B type inclusion

'''B-type inclusions''', formerly also called '''Guarnieri bodies''' ({{pron-en|ɡwɑrˈnjɛri}}) are cellular features found upon [[microscopic]] [[inspection]] of [[epithelial]] [[cell (biology)|cells]] of individuals suspected of having [[poxvirus]]<ref name="urlVariola Virus">{{cite web |url=http://pathport.vbi.vt.edu/pathinfo/pathogens/Variola.html |title=Variola Virus |format= |work= |accessdate=2009-01-02}}</ref> (e.g. [[smallpox]]<ref name="isbn1-55581-240-6">{{cite book |author=Esiri, Margaret M.; Booss, John |title=Viral Encephalitis in Humans |publisher=ASM Press |location=Washington, D.C |year=2003 |pages=117  |isbn=1-55581-240-6 |oclc= |doi= |accessdate=}}</ref> or [[vaccinia]]). In cells stained with [[eosin]], they appear as pink blobs in the [[cytoplasm]] of affected [[epithelial]] cells. The absence of ''Guarnieri bodies'' cannot be used as to rule out [[smallpox]], however, as more sensitive test need to be performed. 

B-type inclusions are the sites of viral replication and are found in all poxvirus-infected cells, unlike A-type inclusions which are more strongly eosinophilic and only found in infections with certain poxviruses. <ref>{{cite book
  | last = Binns
  | first = Matthew M.
  | coauthors = [[Geoffrey L. Smith]], Marion E. Andrew, Marc Artois, Michel Aubert, Jean Blancou, Michael E. G. Boursnell, David B. Boyle, Bernard Brochier, R. Mark L. Buller, Gilles Chappuis, Barbara E. H. Coupar
  | title = Recombinant Poxviruses
  | publisher = CRC Press
  | date = 1992
  | location = Boca Raton, Florida, United States
  | pages = 343
  | url = http://books.google.com/?id=E1pC2Q8DnucC
  | isbn = 0-8493-6179-6}} </ref>

They are named after the [[Italy|Italian]] [[physician]] [[Giuseppe Guarnieri]].

==References==
{{reflist}}

==Further reading==
* {{cite journal |author=GOODPASTURE EW |title=Cytoplasmic inclusions resembling Guarnieri bodies, and other phenomena induced by mutants of the virus of fowlpox |journal=Am. J. Pathol. |volume=35 |issue=2 |pages=213–31 |year=1959 |pmid=13627123 |pmc=1934859 |doi= |url=}}

{{Eponymous medical signs for infectious disease}}

[[Category:Medical terms]]
[[Category:Virology]]


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