View source for Bradykinin receptor

{{protein
| Name = [[bradykinin receptor B1]]
| caption = 
| image = 
| width = 
| HGNCid = 1029
| Symbol = BDKRB1
| AltSymbols = 
| EntrezGene = 623
| OMIM = 600337
| RefSeq = NM_000710
| UniProt = P46663
| PDB = 
| ECnumber = 
| Chromosome = 14
| Arm = q
| Band = 32.1
| LocusSupplementaryData = -32.2
}}
{{protein
| Name = [[bradykinin receptor B2]]
| caption = 
| image = 
| width = 
| HGNCid = 1030
| Symbol = BDKRB2
| AltSymbols = 
| EntrezGene = 624
| OMIM = 113503
| RefSeq = NM_000623
| UniProt = P30411
| PDB = 
| ECnumber = 
| Chromosome = 14
| Arm = q
| Band = 32.1
| LocusSupplementaryData = -32.2
}}
The '''bradykinin receptor''' family is a group of [[G-protein coupled receptor]]s whose principal [[ligand]] is the protein [[bradykinin]].

There are two Bradykinin receptors: the [[bradykinin receptor B1|B<sub>1</sub> receptor]] and the [[bradykinin receptor B2|B<sub>2</sub> receptor]].<ref name="pmid15734727">{{cite journal | author = Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL | title = International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences | journal = Pharmacol. Rev. | volume = 57 | issue = 1 | pages = 27–77 | year = 2005 | pmid = 15734727 | doi = 10.1124/pr.57.1.2 }}</ref> 

==B<sub>1</sub> receptor==
{{Main|bradykinin receptor B1}}

Bradykinin receptor B1 (B<sub>1</sub>) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B<sub>1</sub> receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.

==B<sub>2</sub> receptor==
{{Main|bradykinin receptor B2}}
The B<sub>2</sub> receptor is a [[G protein-coupled receptor]], coupled to [[Gq alpha subunit|G<sub>q</sub>]] and [[Gi alpha subunit|G<sub>i</sub>]]. G<sub>q</sub> stimulates [[phospholipase C]] to increase [[intracellular]] free [[calcium]] and G<sub>i</sub> inhibits [[adenylate cyclase]]. Furthermore, the receptor stimulates the [[mitogen-activated protein kinase]] pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B<sub>2</sub> receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B<sub>2</sub> receptors.<ref name="pmid11230360">{{cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 }}</ref>

[[Icatibant]] is a second generation B<sub>2</sub> receptor antagonist which has undergone limited clinical trials in pain and inflammation.

[[Kallidin]] also signals through the B<sub>2</sub> receptor.

== References ==
{{Reflist}}

==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1330 | title = Bradykinin Receptors  | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{MeshName|Bradykinin+receptor}}

{{transmembranereceptor-stub}}
{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
[[Category:G protein coupled receptors]]

[[de:Bradykininrezeptor]]
[[Category:2Fix]]