View source for Bufadienolide

{{Unreferenced|date=March 2007}}
{{chembox
|ImageFile=Bufadienolide skeletal.svg
|ImageSize=
|IUPACName=5-[(5''R'', 8''R'',9''S'',10''S'',13''S'',14''S'',17''S'')-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one
|OtherNames=
|Section1={{Chembox Identifiers
|  CASNo=
|  PubChem=3035030
|  SMILES=CC14CCC3C2(C)CCCCC2CCC3C1CCC4c5ccc(=O)oc5
|  InChI=1S/C24H34O2/c1-23-13-4-3-5-17(23)7-8-18-20-10-9-19(16-6-11-22(25)26-15-16)24(20,2)14-12-21(18)23/h6,11,15,17-21H,3-5,7-10,12-14H2,1-2H3/t17-,18-,19+,20+,21-,23-,24+/m0/s1
|  InChIKey=YBPMPRDOWHIVNA-JTSGVHQASA-N
  }}
|Section2={{Chembox Properties
|  C=24 | H=34 | O=2
|  MolarMass=
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
  }}
|Section3={{Chembox Hazards
|  MainHazards=
|  FlashPt=
|  Autoignition=
  }}
}}
'''Bufadienolide''' is a type of [[steroid]]. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide [[glycosides]] (bufadienolides that contain structural groups derived from sugars). These are a type of [[cardiac glycoside]], the other being the [[cardenolide]] gylcosides. Both bufadienolides and their glycosides are [[toxic]]; specifically, they are [[Cardiac arrest|heart-arresting]].

== Etymology ==
The term derives from the toad genus ''[[Bufo]]'' that contains bufadienolide glycosides, the suffix ''-adien-'' that refers to the two double bonds in the lactone ring, and the ending ''-olide'' that denotes the [[lactone]] structure. Consequently, related structures with only one double bond are called ''bufenolides''{{Citation needed|date=May 2010}}, and the [[Saturation (chemistry)|saturated]] equivalent is ''bufanolide''.

== Classification ==
According to [[Medical Subject Headings|MeSH]], bufadienolides and bufanolides are classified as follows:

*[[Polycyclic compound]]s
:*[[Steroid]]s
::*[[Cardanolide]]s
:::*[[Cardenolide]]s
:::*[[Cardiac glycoside]]s			
::::*Bufanolides
:::::*[[Bufenolide]]s
:::::*Bufadienolides
::::::*[[Proscillaridin]]
::::::*[[Daigremontianin]]
::::*Cardenolides

Note that cardenolides have been classified under cardanolides as well as cardiac glycosides in this classification.

{{Cardiac glycosides}}

[[Category:Bufanolides]]


{{cardiovascular-drug-stub}}
[[Category:2Fix]]