View source for Certain safety factor

The '''Certain Safety Factor''' is the ratio of the [[lethal dose]] to 1% of population to the [[effective dose]] to 99% of the population (LD1/ED99). This is a better safety index than the [[Median lethal dose|LD<sub>50</sub>]] for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another.

<math>\mbox{Certain safety factor} = \frac{\mathrm{LD}_{1}}{\mathrm{ED}_{99}}</math>

==See also==
* [[Therapeutic index]]
* [[Effective dose]]
* [[IC50|IC<sub>50</sub>]]
* [[LD50|LD<sub>50</sub>]]
* [[EC50|EC<sub>50</sub>]]
* [[Toxicology]]

==References==
http://www.courses.vcu.edu/ptxed/m2/faqs_damaj.htm

[[Category:Pharmacology]]
[[Category:Toxicology]]

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[[pt:Fator de segurança certeiro]]
[[Category:2Fix]]