View source for Competitive antagonist

A '''competitive antagonist''' is a [[receptor antagonist]] that binds to a [[Receptor (biochemistry)|receptor]] but does not activate the receptor. The antagonist will compete with available [[agonist]] for receptor [[binding site]]s on the same receptor. Sufficient antagonist will displace the agonist from the binding sites, resulting in a lower frequency of receptor activation.

Presence of a competitive antagonist will shift an agonism [[dose-response curve]] to the right.<ref name="prism">[http://www.curvefit.com/schild.htm Doseresponse curves in the presence of antagonists<!-- Bot generated title -->]</ref> A [[Schild plot]] for a competitive antagonist will have a slope equal to 1, and the X-intercept and Y-intercept will each equal the [[dissociation constant]] of the antagonist.<ref name="prism"/>

A competitive antagonist can be [[reversible competitive antagonist]] or [[irreversible competitive antagonist]].

==References==
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[[Category:Pharmacology]]
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[[ca:Antagonista competitiu]]
[[de:Kompetitiver Antagonist]]
[[es:Antagonista competitivo]]
[[Category:2Fix]]