View source for Cyclic AMP receptors

{{Pfam_box
| Symbol = Dicty_CAR
| Name = Slime mold cyclic AMP receptor
| image =
| width =
| caption =
| Pfam= PF05462
| Pfam_clan= CL0192
| InterPro= IPR000848
| SMART=
| PROSITE = PDOC00691
| SCOP =
| TCDB =
| OPM family=
| OPM protein=
| PDB=
}}

'''Cyclic AMP receptors ''' from [[slime mold]]s are a distinct family of 
[[G-protein coupled receptors]]. These receptors control development in
[[Dictyostelium discoideum]].

The [[cyclic AMP]] receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes<ref name="PUB00005114">{{cite journal |author=Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL |title=A chemoattractant receptor controls development in Dictyostelium discoideum |journal=Science |volume=241 |issue=4872 |pages=1467–1472 |year=1988 |pmid=3047871 |doi=10.1126/science.3047871}}</ref><ref name="PUB00001912">{{cite journal |author=Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL |title=CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum |journal=Genes Dev. |volume=7 |issue=2 |pages=262–272 |year=1993 |pmid=8436297 |doi=10.1101/gad.7.2.262}}</ref><ref name="PUB00001913">{{cite journal |author=Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL |title=Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development |journal=Genes Dev. |volume=7 |issue=2 |pages=273–282 |year=1993 |pmid=8382181 |doi=10.1101/gad.7.2.273}}</ref>. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

==References==
{{reflist}}

[[Category:G protein coupled receptors]]
[[Category:Protein domains]]
[[Category:Protein families]]
[[Category:Membrane proteins]]
{{transmembranereceptor-stub}}
[[Category:2Fix]]