View source for Fipexide

{{drugbox
| IUPAC_name        = 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-<br>2-(4-chlorophenoxy)ethanone
| image             = Fipexide.png
| CAS_number        = 34161-24-5
| ATC_prefix        = N06
| ATC_suffix        = BX05
| PubChem           = 3351
| DrugBank          =
| C = 20 | H = 21 | Cl = 1 | N = 2 | O = 4
| molecular_weight  = 388.845 g/mol
| bioavailability   =
| protein_bound     =
| metabolism        =
| elimination_half-life =
| excretion         =
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category=
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      =
| routes_of_administration =
}}

'''Fipexide''' ('''Attentil''', '''Vigilor''') is a [[psychoactive drug]] of the [[piperazine]] [[chemical class]] which was developed in [[Italy]] in [[1983]].<ref>Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M. Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level. Bollettino Chimico Farmaceutico. 1983 Feb;122(2):79-85.</ref> It was used as a [[nootropic]] drug in Italy and [[France]], mainly for the treatment of senile dementia,<ref>Bompani R, Scali G. Fipexide, an effective cognition activator in the elderly: a placebo-controlled, double-blind clinical trial. Current Medical Research and Opinion. 1986;10(2):99-106.</ref> but is no longer in common use due to the occurrence of rare adverse drug reactions including [[fever]]<ref>Guy C, Blay N, Rousset H, Fardeau V, Ollagnier M. Fever caused by fipexide. Evaluation of the national pharmacovigilance survey. Therapie. 1990 Sep-Oct;45(5):429-31.</ref> and [[hepatitis]]. Fipexide is similar in action to other nootropic drugs such as [[piracetam]] and is structurally similar to another more well-known nootropic, [[centrophenoxine]]. Chemically, it is an amide union of [[parachlorophenoxyacetate]] and [[methylenedioxybenzylpiperazine]], and notably, has been shown to metabolize to the latter, which plays a significant role in its effects.

==See also==
* [[Befuraline]]
* [[Piberaline]]

==References==
{{Reflist|2}}

{{Stimulants}}
{{Psychostimulants}}
{{Adrenergics}}
{{Dopaminergics}}
{{Serotonergics}}
{{Piperazines}}

[[Category:Nootropics]]
[[Category:Benzodioxoles]]
[[Category:Piperazines]]
[[Category:Amides]]
[[Category:Phenol ethers]]
[[Category:Organochlorides]]


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[[it:Fipexide]]
[[Category:2Fix]]