View source for Hypocretin (orexin) receptor 2

{{PBB|geneid=3062}}
'''Orexin receptor type 2''' ('''Ox2R''' or '''OX<sub>2</sub>'''), also known as  '''hypocretin receptor type 2''', is a [[protein]] that in humans is encoded by the '''HCRTR2''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3062| accessdate = }}</ref>

== Function ==

OX<sub>2</sub> is a [[G-protein coupled receptor]] expressed exclusively in the brain.  It has 64% identity with [[Hypocretin (orexin) receptor 1|OX<sub>1</sub>]].  OX<sub>2</sub> binds both [[orexin]] A and orexin B neuropeptides.  OX<sub>2</sub> is involved in the central feedback mechanism that regulates feeding behaviour.<ref name="entrez">{{cite web | title = Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3062| accessdate = }}</ref>

==Ligands==

===Agonists===
* [[Orexin-A]]
* [[Orexin-B]]
* SB-668,875

===Antagonists===
* [[Almorexant]] - mixed OX<sub>1/2</sub> antagonist
* [[SB-649,868]] - mixed OX<sub>1/2</sub> antagonist
* [[TCS-OX2-29]] - selective OX<sub>2</sub> antagonist
* 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)urea (600x selective for OX<sub>2</sub> over OX<sub>1</sub>)<ref>McAtee LC, Sutton SW, Rudolph DA, Li X, Aluisio LE, Phuong VK, Dvorak CA, Lovenberg TW, Carruthers NI, Jones TK. Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists. ''Bioorganic and Medicinal Chemistry Letters''. 2004 Aug 16;14(16):4225-9. PMID 15261275</ref>
* (3,4-dimethoxyphenoxy)alkylamino acetamides <ref>Cole AG, Stroke IL, Qin LY, Hussain Z, Simhadri S, Brescia MR, Waksmunski FS, Strohl B, Tellew JE, Williams JP, Saunders J, Appell KC, Henderson I, Webb ML. Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists. ''Bioorganic and Medicinal Chemistry Letters''. 2008 Oct 15;18(20):5420-3. PMID 18815029</ref>

==See also==
* [[Orexin receptor]]

==References==
{{reflist}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3013 | title = Orexin Receptors: OX<sub>2</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Flier JS, Maratos-Flier E |title=Obesity and the hypothalamus: novel peptides for new pathways. |journal=Cell |volume=92 |issue= 4 |pages= 437–40 |year= 1998 |pmid= 9491885 |doi=10.1016/S0092-8674(00)80937-X  }}
*{{cite journal  | author=Willie JT, Chemelli RM, Sinton CM, Yanagisawa M |title=To eat or to sleep? Orexin in the regulation of feeding and wakefulness. |journal=Annu. Rev. Neurosci. |volume=24 |issue=  |pages= 429–58 |year= 2001 |pmid= 11283317 |doi= 10.1146/annurev.neuro.24.1.429 }}
*{{cite journal  | author=Hungs M, Mignot E |title=Hypocretin/orexin, sleep and narcolepsy. |journal=Bioessays |volume=23 |issue= 5 |pages= 397–408 |year= 2001 |pmid= 11340621 |doi= 10.1002/bies.1058 }}
*{{cite journal  | author=de Lecea L, Kilduff TS, Peyron C, ''et al.'' |title=The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 322–7 |year= 1998 |pmid= 9419374 |doi=10.1073/pnas.95.1.322  | pmc=18213  }}
*{{cite journal  | author=Sakurai T, Amemiya A, Ishii M, ''et al.'' |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 4 |pages= 573–85 |year= 1998 |pmid= 9491897 |doi=10.1016/S0092-8674(00)80949-6  }}
*{{cite journal  | author=Sakurai T, Amemiya A, Ishii M, ''et al.'' |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 5 |pages= 1 page following 696 |year= 1998 |pmid= 9527442 |doi=10.1016/S0092-8674(00)80949-6  }}
*{{cite journal  | author=Peyron C, Faraco J, Rogers W, ''et al.'' |title=A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. |journal=Nat. Med. |volume=6 |issue= 9 |pages= 991–7 |year= 2000 |pmid= 10973318 |doi= 10.1038/79690 }}
*{{cite journal  | author=Wright GJ, Puklavec MJ, Willis AC, ''et al.'' |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. |journal=Immunity |volume=13 |issue= 2 |pages= 233–42 |year= 2000 |pmid= 10981966 |doi=10.1016/S1074-7613(00)00023-6  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Mazzocchi G, Malendowicz LK, Gottardo L, ''et al.'' |title=Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 2 |pages= 778–82 |year= 2001 |pmid= 11158046 |doi=10.1210/jc.86.2.778  }}
*{{cite journal  | author=Blanco M, López M, García-Caballero T, ''et al.'' |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 4 |pages= 1616–9 |year= 2001 |pmid= 11297593 |doi=10.1210/jc.86.4.1616  }}
*{{cite journal  | author=Blanco M, López M, GarcIa-Caballero T, ''et al.'' |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 1616–9 |year= 2001 |pmid= 11443222 |doi=10.1210/jc.86.4.1616  }}
*{{cite journal  | author=Karteris E, Randeva HS, Grammatopoulos DK, ''et al.'' |title=Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4512–9 |year= 2001 |pmid= 11549701 |doi=10.1210/jc.86.9.4512  }}
*{{cite journal  | author=Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW |title=Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 10 |pages= 4808–13 |year= 2001 |pmid= 11600545 |doi=10.1210/jc.86.10.4808  }}
*{{cite journal  | author=Olafsdóttir BR, Rye DB, Scammell TE, ''et al.'' |title=Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. |journal=Neurology |volume=57 |issue= 10 |pages= 1896–9 |year= 2002 |pmid= 11723285 |doi=  }}
*{{cite journal  | author=Blanco M, García-Caballero T, Fraga M, ''et al.'' |title=Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas. |journal=Regul. Pept. |volume=104 |issue= 1-3 |pages= 161–5 |year= 2002 |pmid= 11830291 |doi=10.1016/S0167-0115(01)00359-7  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
}}
{{refend}}

{{transmembranereceptor-stub}}
{{NLM content}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]

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