View source for Ladostigil

{{Drugbox
| IUPAC_name               = [(3''R'')-3-(prop-2-ynylamino)indan-5-yl]-''N''-propylcarbamate
| image                    = Ladostigil.png
| CAS_number               = 209349-27-4
| ATC_prefix               = none
| ATC_suffix               = 
| PubChem                  = 208907
| ChemSpiderID             = 181005
| C = 16 | H = 20 | N = 2 | O = 2
| molecular_weight         = 272.34 g/mol
| synonyms                 = [''N''-propargyl-(''3R'')-aminoindan-5yl]-''N''-propylcarbamate
| bioavailability          = 
| metabolism               = 
| elimination_half-life    = 
| excretion                = 
| pregnancy_category       = 
| legal_status             = Uncontrolled
| routes_of_administration = Oral
}}

'''Ladostigil''' ('''TV-3,326''') is a novel [[neuroprotective]] [[drug|agent]] being investigated for the treatment of [[neurodegenerative disorder]]s like [[Alzheimer's disease]], [[Lewy body disease]], and [[Parkinson's disease]].<ref name="pmid11205137">{{cite journal | author = Weinstock M, Bejar C, Wang RH, ''et al.'' | title = TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease | journal = Journal of Neural Transmission. Supplementum | volume = | issue = 60 | pages = 157–69 | year = 2000 | pmid = 11205137 | doi = | url = }}</ref> It acts as a [[reversible inhibition|reversible]] [[acetylcholinesterase]] and [[butyrylcholinesterase]] [[enzyme inhibitor|inhibitor]], and an [[irreversible inhibition|irreversible]] [[monoamine oxidase B]] [[enzyme inhibitor|inhibitor]], and combines the [[mechanism of action|mechanisms of action]] of older drugs like [[rivastigmine]] and [[rasagiline]] into a single molecule.<ref name="pmid19110207">{{cite journal | author = Weinreb O, Mandel S, Bar-Am O, ''et al.'' | title = Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs | journal = Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics | volume = 6 | issue = 1 | pages = 163–74 | year = 2009 | month = January | pmid = 19110207 | doi = 10.1016/j.nurt.2008.10.030 | url = http://linkinghub.elsevier.com/retrieve/pii/S1933-7213(08)00226-2}}</ref><ref name="pmid17017566">{{cite journal | author = Weinstock M, Luques L, Bejar C, Shoham S | title = Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression | journal = Journal of Neural Transmission. Supplementum | volume = | issue = 70 | pages = 443–6 | year = 2006 | pmid = 17017566 | doi = | url = }}</ref> In addition to its neuroprotective properties, ladostigil enhances the expression of [[neurotrophic factor]]s like [[glial cell line-derived neurotrophic factor|GDNF]] and [[brain-derived neurotrophic factor|BDNF]], and may be capable of reversing some of the damage seen in neurodegenerative diseases via the induction of [[neurogenesis]].<ref name="pmid18077571">{{cite journal | author = Weinreb O, Amit T, Bar-Am O, Youdim MB | title = Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy | journal = Annals of the New York Academy of Sciences | volume = 1122 | issue = | pages = 155–68 | year = 2007 | month = December | pmid = 18077571 | doi = 10.1196/annals.1403.011 | url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2007&volume=1122&spage=155}}</ref> Ladostigil also has [[antidepressant]] effects, and may be useful for treating comorbid [[Major depressive disorder|depression]] and [[anxiety]] often seen in such diseases as well.<ref name="pmid11889501">{{cite journal | author = Weinstock M, Poltyrev T, Bejar C, Youdim MB | title = Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression | journal = Psychopharmacology | volume = 160 | issue = 3 | pages = 318–24 | year = 2002 | month = March | pmid = 11889501 | doi = 10.1007/s00213-001-0978-x | url = http://dx.doi.org/10.1007/s00213-001-0978-x}}</ref><ref name="pmid12787840">{{cite journal | author = Weinstock M, Gorodetsky E, Poltyrev T, Gross A, Sagi Y, Youdim M | title = A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease | journal = Progress in Neuro-psychopharmacology & Biological Psychiatry | volume = 27 | issue = 4 | pages = 555–61 | year = 2003 | month = June | pmid = 12787840 | doi = 10.1016/S0278-5846(03)00053-8 | url = http://linkinghub.elsevier.com/retrieve/pii/S0278-5846(03)00053-8}}</ref>

== See also ==
* [[Rasagiline]]
* [[Selegiline]]

== References ==
{{Reflist}}


{{Antioxidants}}
{{Antidementia}}
{{Antiparkinson}}
{{Nootropics}}
{{Antidepressants}}
{{Cholinergics}}
{{Dopaminergics}}

[[Category:Acetylcholinesterase inhibitors]]
[[Category:Indanes]]
[[Category:Alkynes]]
[[Category:Carbamates]]
[[Category:2Fix]]