View source for Metabotropic glutamate receptor 6

{{PBB|geneid=2916}}
'''Glutamate receptor, metabotropic 6''', also known as '''GRM6''', is a [[protein]] which in humans is encoded by the ''GRM6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM6 glutamate receptor, metabotropic 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2916| accessdate = }}</ref><ref name="pmid9215706">{{cite journal | author = Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, Nakanishi S | title = The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6 | journal = Eur. J. Neurosci. | volume = 9 | issue = 6 | pages = 1226–35 | year = 1997 | month = June | pmid = 9215706 | doi = 10.1111/j.1460-9568.1997.tb01477.x| url =  }}</ref>

== Function ==

L-[[glutamate]] is the major excitatory [[neurotransmitter]] in the [[central nervous system]] and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The [[metabotropic glutamate receptor]]s are a family of [[G protein-coupled receptor]]s, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes [[GRM1]] and [[GRM5]] and these receptors have been shown to activate [[phospholipase C]]. Group II includes [[Metabotropic glutamate receptor 2|GRM2]] and [[Metabotropic glutamate receptor 3|GRM3]], while Group III includes [[Metabotropic glutamate receptor 4|GRM4]], GRM6, [[Metabotropic glutamate receptor 7|GRM7]] and [[Metabotropic glutamate receptor 8|GRM8]]. Group II and III receptors are linked to the inhibition of the [[cyclic AMP]] cascade but differ in their agonist selectivities.<ref name="entrez">{{cite web | title = Entrez Gene: GRM6 glutamate receptor, metabotropic 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2916| accessdate = }}</ref>

==See also==
* [[Metabotropic glutamate receptor]]

==References==
{{reflist}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2278 | title = Metabotropic Glutamate Receptors: mGlu<sub>6</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Hashimoto T, Inazawa J, Okamoto N, ''et al.'' |title=The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. |journal=Eur. J. Neurosci. |volume=9 |issue= 6 |pages= 1226–35 |year= 1997 |pmid= 9215706 |doi=10.1111/j.1460-9568.1997.tb01477.x  }}
*{{cite journal  | author=Dhingra A, Lyubarsky A, Jiang M, ''et al.'' |title=The light response of ON bipolar neurons requires G[alpha]o. |journal=J. Neurosci. |volume=20 |issue= 24 |pages= 9053–8 |year= 2001 |pmid= 11124982 |doi=  }}
*{{cite journal  | author=Valerio A, Ferraboli S, Paterlini M, ''et al.'' |title=Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. |journal=Gene |volume=262 |issue= 1-2 |pages= 99–106 |year= 2001 |pmid= 11179672 |doi=10.1016/S0378-1119(00)00547-3  }}
*{{cite journal  | author=Dryja TP, McGee TL, Berson EL, ''et al.'' |title=Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 13 |pages= 4884–9 |year= 2005 |pmid= 15781871 |doi= 10.1073/pnas.0501233102  | pmc=555731 }}
*{{cite journal  | author=Zeitz C, van Genderen M, Neidhardt J, ''et al.'' |title=Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 11 |pages= 4328–35 |year= 2005 |pmid= 16249515 |doi= 10.1167/iovs.05-0526 }}
*{{cite journal  | author=Zeitz C, Forster U, Neidhardt J, ''et al.'' |title=Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. |journal=Hum. Mutat. |volume=28 |issue= 8 |pages= 771–80 |year= 2007 |pmid= 17405131 |doi= 10.1002/humu.20499 }}
}}
{{refend}}

{{transmembranereceptor-stub}}
{{NLM content}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]

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[[pt:Receptor metabotrópico de glutamato 6]]
[[Category:2Fix]]