View source for Mollaret's meningitis

{{DiseaseDisorder infobox
 | Name           = Mollaret's meningitis
 | Image          = Meninges-en.svg
 | Caption        = Meninges of the central nervous system: dura mater, arachnoid, and pia mater.
 | DiseasesDB     = 
 | ICD10          = 
 | ICD9           = {{ICD9|047.9}}
 | MedlinePlus    = 
 | eMedicineSubj  = neuro
 | eMedicineTopic = 697
 | eMedicine_mult = 
 | MeshID         = D008582
 }}

'''Mollaret's meningitis''' is a recurrent [[inflammation]] of the protective membranes covering the [[brain]] and [[spinal cord]], known collectively as the [[meninges]]. Mollaret's meningitis is caused by [[herpes simplex virus]]. It is a recurrent, benign, [[aseptic meningitis]].

It is named for [[Pierre Mollaret]].<ref>{{WhoNamedIt|synd|1537}}</ref><ref>P. Mollaret. Méningite endothélio-leucocytaire multirécurrente bénigne. Syndrome nouveau ou maladie nouvelle? (Documents cliniques). Revue neurologique, Paris, 1944, 76: 57-76.</ref>

==Signs and symptoms==
Mollaret's meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever; cerebrospinal fluid (CSF) pleocytosis with large "endothelial" cells, neutrophils, and lymphocytes; and attacks separated by symptom-free periods of weeks to months; and spontaneous remission of symptoms and signs. Many people have side effects between bouts that vary from chronic daily headaches to after-effects from meningitis such as hearing loss. Some patients report short bouts of 3–7 days of being sick while others have cases that can last for weeks or months. Many references talk about brief acute cases but support groups of people with Mollaret's show a wide variety of lengths of each bout. Some patients also report frequent shingles outbreaks. The chickenpox virus is part of the herpes family. <ref>Mollaret's meningitis at patient.co.uk</ref>

==Diagnosis==

Investigations include [[blood test]]s (electrolytes, liver and kidney function, inflammatory markers and a [[complete blood count]]) and usually [[X-ray]] examination of the chest. The most important test in identifying or ruling out meningitis is analysis of the cerebrospinal fluid (fluid that envelops the brain and the spinal cord) through [[lumbar puncture]] (LP). However, if the patient is at risk for a cerebral mass lesion or elevated [[intracranial pressure]] (recent head injury, a known immune system problem, localizing neurological signs, or evidence on examination of a raised ICP), a lumbar puncture may be contraindicated because of the possibility of fatal [[brain herniation]]. In such cases a [[Computed tomography|CT]] or [[Magnetic resonance imaging|MRI]] scan is generally performed prior to the lumbar puncture to exclude this possibility. Otherwise, the CT or MRI should be performed after the LP, with MRI preferred over CT due to its superiority in demonstrating areas of cerebral edema, ischemia, and meningeal inflammation.

During the lumbar puncture procedure, the opening pressure is measured. A pressure of over 180&nbsp;mm H<sub>2</sub>O is suggestive of bacterial meningitis.

Mollaret's meningitis is suspected based on clinical criteria and confirmed by HSV 1 or HSV 2 on PCR of CSF, although not all cases test positive.

==Treatment==
===Initial treatment===
[[Acyclovir]] is the treatment of choice for Mollaret's meningitis. Some patients see a drastic difference in how often they get sick and others don't. Often treatment means managing symptoms, such as pain management and strengthening the immune system.

==See also==
* [[Encephalitis]]
* [[Meningitis]]
* [[Herpes simplex virus]]

==References==
{{reflist}}

{{Viral diseases}}
{{Diseases of the nervous system}}

[[Category:Diseases involving the fasciae]]
[[Category:Inflammations]]
[[Category:Medical emergencies]]
[[Category:Neurological disorders]]
[[Category:Meningitis]]
[[Category:2Fix]]