View source for Open-label trial

An '''open-label trial''' or '''open trial''' is a type of [[clinical trial]] in which both the researchers and participants know which treatment is being administered.<ref name="urlDefinition: open-label trial from Online Medical Dictionary">{{cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?open-label+trial |title=Definition: open-label trial from Online Medical Dictionary |format= |work= |accessdate=}}</ref>
<ref>{{cite web
|url=http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=285990
|title=Open label study entry in the public domain NCI Dictionary of Cancer Terms}}</ref>
This contrasts with single blind and [[double blind]] experimental designs, where participants are not aware of what treatment they are receiving (researchers are also unaware in a double blind trial). 

Open-label trials may be appropriate for comparing two very similar treatments to determine which is most effective.  An open-label trial may be unavoidable under some circumstances, such as comparing the effectiveness of a medication to intensive physical therapy sessions.
 
An open-label trial may still be [[randomized controlled trial|randomized]].  Open-label trials may also be uncontrolled, with all participants receiving the same treatment.

==References==
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{{Medical research studies}}

[[Category:Experimental design]]
[[Category:Pharmacology]]
[[Category:Clinical research]]
[[Category:Scientific method]]
[[Category:Medical research]]
[[Category:Medical statistics]]

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