View source for Osemozotan

{{Drugbox
| IUPAC_name               = 5-(3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy)-1,3-benzodioxole
| image                    = Osemozotan.png
| CAS_number               = 137275-80-0
| ATC_prefix               = 
| ATC_suffix               = 
| PubChem                  = 198746
| ChemSpiderID             = 
| C = 20 | H = 23 | N = 1 | O = 4
| molecular_weight         = 341.400 g/mol
| smiles                   = c4cc1OCOc1cc4OCCCNCC3CCc2ccccc2O3
| bioavailability          = 
| metabolism               = 
| elimination_half-life    = 
| excretion                = 
| pregnancy_category       = 
| legal_status             = Uncontrolled
| routes_of_administration = 
}}

'''Osemozotan''' ('''MKC-242''') is a [[binding selectivity|selective]] [[5-HT1A receptor|5-HT<sub>1A</sub> receptor]] [[agonist]] with some [[functional selectivity]], acting as a [[full agonist]] at presynaptic and a [[partial agonist]] at postsynaptic 5-HT<sub>1A</sub> receptors.<ref>{{Cite pmid|8786639}}</ref> It has [[antidepressant]] and [[anxiolytic]] effects in animal studies,<ref>{{Cite pmid|8768745}}</ref><ref>{{Cite pmid|12498918}}</ref> and is used to investigate the role of 5-HT<sub>1A</sub> receptors in modulating the release of [[dopamine]] and [[serotonin]] in the brain,<ref>{{Cite pmid|10696105}}</ref><ref>{{Cite pmid|14614948}}</ref> and their involvement in addiction to abused stimulants such as cocaine and methamphetamine.<ref>{{Cite pmid|16863654}}</ref><ref>{{Cite pmid|16962650}}</ref><ref>{{Cite pmid|18198473}}</ref><ref>{{Cite pmid|19270432}}</ref><ref>{{Cite pmid|19336914}}</ref>

== See also ==
* [[Piclozotan]]
* [[Robalzotan]]
* [[Sarizotan]]

== References ==
{{Reflist}}


{{Serotonergics}}

[[Category:Benzodioxoles]]
[[Category:Phenol ethers]]
[[Category:Benzodioxans]]



{{pharmacology-stub}}
[[Category:2Fix]]