View source for Osler's node

[[File:Osler Nodules Hand.jpg|thumb|200px|Osler's lesions found on the hand and fingers of a 43 year old male with subacute bacterial endocarditis.]]
'''Osler's nodes''' are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including [[infective endocarditis]], and are caused by [[immune complex]] deposition. They are named after Sir [[William Osler]] who described them in the early 20th century.<ref>{{WhoNamedIt|synd|1702}}</ref><ref>W. Osler. Chronic infectious endocarditis. Quarterly Journal of Medicine, Oxford, 1908-1909, 2: 219-230.</ref> Their presence is one definition of [[Osler's sign]].<ref>{{DorlandsDict|seven/000097190|Osler sign}}</ref>

==Causes==
Osler's nodes result from the deposition of [[immune complex]]es.{{Citation needed|date=May 2009}} The resulting [[inflammation|inflammatory response]] leads to swelling, redness, and pain that characterize these lesions.

The nodes are commonly indicative of [[subacute bacterial endocarditis]].<ref>{{DorlandsDict|six/000072701|Osler nodes}}</ref> 10–25% of endocarditis patients will have Osler's nodes.{{Citation needed|date=December 2008}} Other signs of endocarditis include [[Roth's spot]]s and [[Janeway lesion]]s. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are nontender.<ref name="pmid947688">{{cite journal |title=A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal=Chest |volume=70 |issue=2 |pages=239–43 |year=1976 |month=August |pmid=947688 |doi= 10.1378/chest.70.2.239|url=http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=947688 |author1=Farrior JB |author2=Silverman ME |author-separator=, |author-name-separator=}}</ref>

It can also be seen in
* [[Lupus erythematosus|systemic lupus erythematosus]]
* [[marantic endocarditis]] 
* disseminated [[gonococcus|gonococcal]] infection
* distal to infected arterial [[catheter]]

==External links==
*[http://er119test.blogspot.com/2007/07/osler-or-janeway.html Picture of Osler's nodes and Janeway's lesions]

==References==
{{reflist}}

{{Eponymous medical signs for circulatory and respiratory systems}}






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[[de:Osler-Knötchen]]
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[[pl:Guzek Oslera]]

[[Category:Medical signs]]
[[Category:2Fix]]