View source for Purinergic receptor

'''Purinergic receptors''', also known as purinoceptors, are a family of newly characterized [[plasma membrane]] molecules involved in several cellular functions such as vascular reactivity, [[apoptosis]] and [[cytokine]] secretion. These functions have not been well characterized and the effect of the extracellular microenvironment on their function is also poorly understood.

[[Fibroblasts]] share several features with [[smooth muscle]] cells and are an important constituent of the [[atherosclerotic]] plaque. 

These receptors have their effect of high [[glucose]] concentration on [[Adenosine triphosphate|ATP]]-mediated responses in human fibroblasts.

The members of the family include the following:

{| class="wikitable"
| '''Name''' || '''Activation''' || '''Class'''
 |- 
 | [[P1 receptors]] || [[adenosine]] || [[G protein-coupled receptor|G protein-coupled receptors]]
 |- 
 | [[P2Y receptors]]  || [[nucleotide]]s
*[[Adenosine triphosphate|ATP]]
*[[Adenosine diphosphate|ADP]]
*[[Uridine triphosphate|UTP]]
*[[Uridine diphosphate|UDP]]
*[[UDP-glucose]] 
|| [[G protein-coupled receptor|G protein-coupled receptors]]
 |- 
 | [[P2X receptors]] || [[adenosine triphosphate|ATP]] || [[ligand-gated ion channel]]
|}

==Inhibitors==
Inhibitors of purinergic receptors include [[clopidogrel]], [[prasugrel]] and [[ticlopidine]], as well as the investigational drug [[ticagrelor]]. All of these are [[antiplatelet agent]]s that block [[P2Y12|P2Y<sub>12</sub>]] receptors.

==External links==
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1273 IUPHAR GPCR Database - Adenosine receptors]
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1294 IUPHAR GPCR Database - P2Y receptors]
* {{MeshName|Purinergic+Receptors}}

[[Category:G protein coupled receptors]]

{{transmembranereceptor-stub}}
{{Transmembrane receptors}}
{{Ligand-gated ion channels}}
{{G protein-coupled receptors}}

[[pt:Receptor purinérgico]]
[[zh:嘌呤受体]]
[[Category:2Fix]]