View source for Somatostatin receptor 5

{{PBB|geneid=6755}}
'''Somatostatin receptor type 5''' is a [[protein]] that in humans is encoded by the ''SSTR5'' [[gene]].<ref name="pmid7607700">{{cite journal | author = Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI | title = Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization | journal = Genomics | volume = 26 | issue = 3 | pages = 638–9 | year = 1995 | month = Aug | pmid = 7607700 | pmc =  | doi =10.1016/0888-7543(95)80195-R  }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins.  The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.  SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.<ref name="entrez">{{cite web | title = Entrez Gene: SSTR5 somatostatin receptor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6755| accessdate = }}</ref>
}}

==See also==
* [[Somatostatin receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Yamada Y, Post SR, Wang K, ''et al.'' |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251–5 |year= 1992 |pmid= 1346068 |doi=10.1073/pnas.89.1.251  | pmc=48214  }}
*{{cite journal  | author=Montminy MR, Goodman RH, Horovitch SJ, Habener JF |title=Primary structure of the gene encoding rat preprosomatostatin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 11 |pages= 3337–40 |year= 1984 |pmid= 6145156 |doi=10.1073/pnas.81.11.3337  | pmc=345502  }}
*{{cite journal  | author=Panetta R, Greenwood MT, Warszynska A, ''et al.'' |title=Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. |journal=Mol. Pharmacol. |volume=45 |issue= 3 |pages= 417–27 |year= 1994 |pmid= 7908405 |doi=  }}
*{{cite journal  | author=O'Carroll AM, Raynor K, Lolait SJ, Reisine T |title=Characterization of cloned human somatostatin receptor SSTR5. |journal=Mol. Pharmacol. |volume=46 |issue= 2 |pages= 291–8 |year= 1994 |pmid= 8078491 |doi=  }}
*{{cite journal  | author=Yamada Y, Kagimoto S, Kubota A, ''et al.'' |title=Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 844–52 |year= 1993 |pmid= 8373420 |doi=10.1006/bbrc.1993.2122  }}
*{{cite journal  | author=Yamada Y, Stoffel M, Espinosa R, ''et al.'' |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449–52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088 }}
*{{cite journal  | author=Fukusumi S, Kitada C, Takekawa S, ''et al.'' |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252 }}
*{{cite journal  | author=Ain KB, Taylor KD, Tofiq S, Venkataraman G |title=Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 6 |pages= 1857–62 |year= 1997 |pmid= 9177396 |doi=10.1210/jc.82.6.1857  }}
*{{cite journal  | author=de Lecea L, Ruiz-Lozano P, Danielson PE, ''et al.'' |title=Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. |journal=Genomics |volume=42 |issue= 3 |pages= 499–506 |year= 1997 |pmid= 9205124 |doi= 10.1006/geno.1997.4763 }}
*{{cite journal  | author=Jaïs P, Terris B, Ruszniewski P, ''et al.'' |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639–44 |year= 1997 |pmid= 9279525 |doi=10.1046/j.1365-2362.1997.1740719.x  }}
*{{cite journal  | author=Hukovic N, Panetta R, Kumar U, ''et al.'' |title=The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 21416–22 |year= 1998 |pmid= 9694905 |doi=10.1074/jbc.273.33.21416  }}
*{{cite journal  | author=Sharma K, Patel YC, Srikant CB |title=C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 82–90 |year= 1999 |pmid= 9892014 |doi=10.1210/me.13.1.82  }}
*{{cite journal  | author=Kumar U, Sasi R, Suresh S, ''et al.'' |title=Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. |journal=Diabetes |volume=48 |issue= 1 |pages= 77–85 |year= 1999 |pmid= 9892225 |doi=10.2337/diabetes.48.1.77  }}
*{{cite journal  | author=Rocheville M, Lange DC, Kumar U, ''et al.'' |title=Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7862–9 |year= 2000 |pmid= 10713101 |doi=10.1074/jbc.275.11.7862  }}
*{{cite journal  | author=Rocheville M, Lange DC, Kumar U, ''et al.'' |title=Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. |journal=Science |volume=288 |issue= 5463 |pages= 154–7 |year= 2000 |pmid= 10753124 |doi=10.1126/science.288.5463.154  }}
*{{cite journal  | author=Daniels RJ, Peden JF, Lloyd C, ''et al.'' |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339  }}
*{{cite journal  | author=Ballarè E, Persani L, Lania AG, ''et al.'' |title=Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 8 |pages= 3809–14 |year= 2001 |pmid= 11502816 |doi=10.1210/jc.86.8.3809  }}
*{{cite journal  | author=Pasquali D, Notaro A, Esposito D, ''et al.'' |title=[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy] |journal=Minerva Endocrinol. |volume=26 |issue= 3 |pages= 175–9 |year= 2002 |pmid= 11753241 |doi=  }}
*{{cite journal  | author=Papotti M, Bongiovanni M, Volante M, ''et al.'' |title=Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. |journal=Virchows Arch. |volume=440 |issue= 5 |pages= 461–75 |year= 2002 |pmid= 12021920 |doi= 10.1007/s00428-002-0609-x }}
}}
{{refend}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2435 | title = Somatostatin Receptors: sst<sub>5</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{MeshName|somatostatin+receptor+5}}

{{G protein-coupled receptors}}
{{transmembranereceptor-stub}}
{{NLM content}}
[[Category:G protein coupled receptors]]

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[[Category:2Fix]]