Difference between revisions of "Fluocinolone acetonide"

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Fluocinolone acetonide
File:Fluocinolone acetonide.svg
Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
Pregnancy
category
  • C
Routes of
administration		 Topical
Pharmacokinetic data
Metabolism Hepatic, CYP3A4-mediated
Biological half-life 1.3 to 1.7 hours
Identifiers
CAS Number 67-73-2
ATC code C05AA10 (WHO) D07AC04 S01BA15 S02BA08
PubChem CID 6215
DrugBank APRD00977
Chemical data
Formula C24H30F2O6
Molar mass 452.488 g/mol[[Script error: No such module "String".]]
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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
Pregnenedione
(+20-one)
Rimexolone · HALOGENATED, WITH FG AT 16: Flunisolide · Triamcinolone · Amcinonide · Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) · HALOGENATED AT 9: Fluorometholone · HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) · Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Pregnatriene
(+2-ene)
Other/ungrouped
HALOGENATED: Loteprednol · HALOGENATED, WITH FG AT 16: Fludroxycortide · Formocortal · Mometasone furoate
Aldosterone antagonists
Synthesis modifiers
Antihemorrhoidals for topical use
Antivaricose therapy
Capillary stabilising agents
Anti-infectives
Corticosteroids
Betamethasone • Dexamethasone • Fluocinolone acetonide • Hydrocortisone • Prednisolone
Analgesics and anesthetics

M: EAR

anat(e, p)/phys/devp

proc, drug(S2)


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es:Acetónido de fluocinolona

it:Fluocinolone acetonide hu:Fluocinolon-acetonid pl:Fluocynolon uk:Флуоцинолон ацетонід

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