Difference between revisions of "Hydrochloride"
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Latest revision as of 10:01, 20 September 2010
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In chemistry, hydrochlorides are salts resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (mostly amines). This is also known as muriate, derived from hydrochloric acid's other name: muriatic acid.
For example, reaction of pyridine (C5H5N) with hydrochloric acid (HCl) yields pyridine hydrochloride (C5H5N·HCl). Even though this style of formula is often used for denoting the hydrochlorides, the dot incorrectly implies that the two molecules are weakly bonded together; rather, what is present is the salt C5H5NH+ Cl- with correct chemical name pyridinium chloride.
Uses
Converting insoluble amines into hydrochlorides is a common way to make them water- and acid-soluble. This is particularly desirable for substances used in medications. Many pharmaceutical substances are prepared as hydrochlorides so that they may be quickly released in the gastrointestinal tract; the body usually absorbs a hydrochloride within fifteen or thirty minutes. Very often hydrochlorides of amines have longer shelf-lives than their respective free bases.
Examples of hydrochlorides in medical uses are many, ranging from over-the-counter sinus relief to antidepressants.
See also
fr:Chlorhydrate it:Cloridrato nl:Waterstofchloride pl:chlorowodorki pt:Cloridrato sv:Hydroklorid zh:有机盐酸盐
