Difference between revisions of "Bufadienolide"

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Bufadienolide is a type of steroid. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide gylcosides. Both bufadienolides and their glycosides are toxic; specifically, they are heart-arresting.

Etymology

The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides^{[citation needed]}, and the saturated equivalent is bufanolide.

Classification

According to MeSH, bufadienolides and bufanolides are classified as follows:

• Polycyclic compounds

• Steroids

• Cardanolides

• Cardenolides
• Cardiac glycosides

• Bufanolides

• Bufenolides
• Bufadienolides

• Proscillaridin
• Daigremontianin

• Cardenolides

Note that cardenolides have been classified under cardanolides as well as cardiac glycosides in this classification.