Difference between revisions of "Template:PBB/351"

Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
	250px; PDB rendering based on 1aap.
Available structures
PDB	1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1brc, 1ca0, 1iyt, 1mwp, 1owt, 1rw6, 1taw, 1tkn, 1z0q, 1zjd, 2beg, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47
Identifiers
Symbols	APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2
External IDs	OMIM: 104760 MGI: 88059 HomoloGene: 56379 GeneCards: APP Gene
Gene Ontology
Molecular function	• DNA binding; • serine-type endopeptidase inhibitor activity; • binding; • iron ion binding; • copper ion binding; • heparin binding; • zinc ion binding; • identical protein binding; • metal ion binding;
Cellular component	• extracellular region; • membrane fraction; • cytoplasm; • Golgi apparatus; • integral to plasma membrane; • coated pit; • cell surface; • membrane; • integral to membrane; • axon; • cytoplasmic vesicle; • neuromuscular junction; • ciliary rootlet; • apical part of cell; • perinuclear region of cytoplasm; • spindle midzone;
Biological process	• G2 phase of mitotic cell cycle; • suckling behavior; • mRNA polyadenylation; • cellular copper ion homeostasis; • endocytosis; • apoptosis; • cell adhesion; • Notch signaling pathway; • axonogenesis; • mating behavior; • axon cargo transport; • adult locomotory behavior; • visual learning; • axon midline choice point recognition; • neuron remodeling; • dendrite development; • extracellular matrix organization and biogenesis; • forebrain development; • regulation of body size; • positive regulation of progression through mitotic cell cycle; • positive regulation of transcription from RNA polymerase II promoter; • collateral sprouting in the absence of injury; • regulation of synapse structure and activity; • regulation of balance; • neuromuscular process; • synaptic growth at neuromuscular junction; • smooth endoplasmic reticulum calcium ion homeostasis;
	Sources: Amigo / EGO
RNA expression pattern
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	More reference expression data
Orthologs

Latest revision as of 21:18, 21 September 2010

Difference between revisions of "Template:PBB/351"

Latest revision as of 21:18, 21 September 2010

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Revision as of 01:24, 25 September 2009 (view source) BogBot (Talk) m (unnest {{tl\|GNF Ortholog box}})	Latest revision as of 21:18, 21 September 2010 (view source) Jontas (Talk \| contribs) m (1 revision)
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