Chemical substance

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Water and steam are two different forms of the same chemical substance.

In chemistry, a chemical substance is a material with a specific chemical composition.

A common example of a chemical substance is pure water; it has the same properties and the same ratio of hydrogen to oxygen whether it is isolated from a river or made in a laboratory. Some typical chemical substances are diamond, gold, salt (sodium chloride) and sugar (sucrose). Generally, chemical substances exist as a solid, liquid, gas, or plasma and may change between these phases of matter with changes in temperature or pressure. Chemical reactions convert one chemical substance into another.

Forms of energy, such as light and heat, are not considered to be matter, and thus they are not "substances" in this regard.

Definition

Chemical substances (also sometimes referred to as a pure substance) are often defined as "any material with a definite chemical composition" in most introductory general chemistry textbooks. According to this definition a chemical substance can either be a pure chemical element or a pure chemical compound. However, there are exceptions to this definition; a pure substance can also be defined as a form of matter that has both definite composition and distinct properties. The chemical substance index published by CAS also includes several alloys of uncertain composition. Non-stoichiometric compounds are a special case (in inorganic chemistry) that violates the law of constant composition, and for them, it is sometimes difficult to draw the line between a mixture and a compound, as in the case of palladium hydride. Broader definitions of chemicals or chemical substances can be found, for example: "the term 'chemical substance' means any organic or inorganic substance of a particular molecular identity, including - (i) any combination of such substances occurring in whole or in part as a result of a chemical reaction or occurring in nature"

History

The concept of a "chemical substance" became firmly established in the late eighteenth century after work by the chemist Joseph Proust on the composition of some pure chemical compounds such as basic copper carbonate. He deduced that, "All samples of a compound have the same composition; that is, all samples have the same proportions, by mass, of the elements present in the compound." This is now known as the law of constant composition. Later with the advancement of methods for chemical synthesis particularly in the realm of organic chemistry; the discovery of many more chemical elements and new techniques in the realm of analytical chemistry used for isolation and purification of elements and compounds from chemicals that led to the establishment of modern chemistry, the concept was defined as is found in most chemistry textbooks. However, there are some controversies regarding this definition mainly because the large number of chemical substances reported in chemistry literature need to be indexed.

Chemical elements

Main article: Chemical element

See also: List of elements by name

An element is a chemical substance that is made up of a particular kind of atoms and hence cannot be broken down or transformed by a chemical reaction into a different element, though it can be transmutated into another element through a nuclear reaction. This is so, because all of the atoms in a sample of an element have the same number of protons, though they may be different isotopes, with differing numbers of neutrons.

There are about 120 known elements, about 80 of which are stable - that is, they do not change by radioactive decay into other elements. However, the number of chemical substances that are elements can be more than 120, because some elements can occur as more than a single chemical substance (allotropes). For instance, oxygen exists as both diatomic oxygen (O₂) and ozone (O₃). The majority of elements are classified as metals. These are elements with a characteristic lustre such as iron, copper, and gold. Metals typically conduct electricity and heat well, and they are malleable and ductile. Around a dozen elements, such as carbon, nitrogen, and oxygen, are classified as non-metals. Non-metals lack the metallic properties described above, they also have a high electronegativity and a tendency to form negative ions. Certain elements such as silicon sometimes resemble metals and sometimes resemble non-metals, and are known as metalloids.

Chemical compounds

Main article: Chemical compound

See also: List of organic compounds and List of inorganic compounds

A pure chemical compound is a chemical substance that is composed of a particular set of molecules or ions. Two or more elements combined into one substance through a chemical reaction form a chemical compound. All compounds are substances, but not all substances are compounds.

A chemical compound can be either atoms bonded together in molecules or crystals in which atoms, molecules or ions form a crystalline lattice. Compounds based primarily on carbon and hydrogen atoms are called organic compounds, and all others are called inorganic compounds. Compounds containing bonds between carbon and a metal are called organometallic compounds.

Compounds in which components share electrons are known as covalent compounds. Compounds consisting of oppositely charged ions are known as ionic compounds, or salts.

In organic chemistry, there can be more than one chemical compound with the same composition and molecular weight. Generally, these are called isomers. Isomers usually have substantially different chemical properties, may be isolated and do not spontaneously convert to each other. A common example is glucose vs. fructose. The former is an aldehyde, the latter is a ketone. Their interconversion requires either enzymatic or acid-base catalysis. However, there are also tautomers, where isomerization occurs spontaneously, such that a pure substance cannot be isolated into its tautomers. A common example is glucose, which has open-chain and ring forms. One cannot manufacture pure open-chain glucose because glucose spontaneously cyclizes to the hemiacetal form.

Substances versus mixtures

Main article: Mixture

All matter consists of various elements and chemical compounds, but these are often intimately mixed together. Mixtures contain more than one chemical substance, and they do not have a fixed composition. In principle, they can be separated into the component substances by purely mechanical processes. Butter, soil and wood are common examples of mixtures.

Grey iron metal and yellow sulfur are both chemical elements, and they can be mixed together in any ratio to form a yellow-grey mixture. No chemical process occurs, and the material can be identified as a mixture by the fact that the sulfur and the iron can be separated by a mechanical process, such as using a magnet to attract the iron away from the sulfur.

In contrast, if iron and sulfur are heated together in a certain ratio (56 grams (1 mol) of iron to 32 grams (1 mol) of sulfur), a chemical reaction takes place and a new substance is formed, the compound iron(II) sulfide, with chemical formula FeS. The resulting compound has all the properties of a chemical substance and is not a mixture. Iron(II) sulfide has its own distinct properties such as melting point and solubility, and the two elements cannot be separated using normal mechanical processes; a magnet will be unable to recover the iron, since there is no metallic iron present in the compound.

Chemicals versus chemical substances

While the term chemical substance is a somewhat technical term used most often by professional chemists, the word chemical is more widely used in the pharmaceutical industry, government and society in general. Thus the word chemical includes a much wider class of substances that includes many mixtures of chemical substances that often find application in many vocations; and is most commonly used only for artificial or processed substances, such as the products of the chemical industry.

Artificial chemicals can be classified by production volume into bulk chemicals, fine chemicals and chemicals found in research only. Bulk chemicals are produced in very large quantities, usually with highly optimized continuous processes and to a relatively low price. Fine chemicals are produced at a high cost in small quantities for special low-volume applications such as biocides, pharmaceuticals and speciality chemicals for technical applications. Research chemicals are produced individually for research, such as when searching for synthetic routes or screening substances for pharmaceutical activity. In effect, their price per gram is very high, although they are not sold.

Naming and indexing

Every chemical substance has one or more systematic names, usually named according to the IUPAC rules for naming. An alternative system is used by the Chemical Abstracts Service (CAS).

Many compounds are also known by their more common, simpler names, many of which predate the systematic name. For example, the long-known sugar glucose is now systematically named 6-(hydroxymethyl)oxane-2,3,4,5-tetrol. Natural products and pharmaceuticals are also given simpler names, for example the mild pain-killer Naproxen is the more common name for the chemical compound (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid.

Chemists frequently refer to chemical compounds using chemical formulae or molecular structure of the compound. There has been a phenomenal growth in the number of chemical compounds being synthesized (or isolated), and then reported in the scientific literature by professional chemists around the world. An enormous number of chemical compounds are possible through the chemical combination of the known chemical elements. At the last count, about thirty million chemical compounds are known. The names of many of these compounds are often nontrivial and hence not very easy to remember or cite accurately. Also it is difficult to keep the track of them in the literature. Several international organizations like IUPAC and CAS have initiated steps to make such tasks easier. CAS provides the abstracting services of the chemical literature, and provides a numerical identifier, known as CAS registry number to each chemical substance that has been reported in the chemical literature (such as chemistry journals and patents). This information is compiled as a database and is popularly known as the Chemical substances index. Other computer-friendly systems that have been developed for substance information, are: SMILES and the International Chemical Identifier or InChI.

Identification of a typical chemical substance

Common name	Systematic name	Chemical formula	Chemical structure	CAS registry number	InChI
alcohol, or ethyl alcohol	ethanol	C2H5OH	60px	[64-17-5]	1/C2H6O/c1-2-3/h3H,2H2,1H3

Isolation, purification, characterization, and identification

Often a pure substance needs to be isolated from a mixture, for example from a natural source (where a sample often contains numerous chemical substances) or after a chemical reaction (which often give mixtures of chemical substances).

See also

• IUPAC nomenclature

Notes and references

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