Ifosfamide

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Ifosfamide
File:Ifosfamide.svg
Systematic (IUPAC) name
N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
Clinical data
Routes of
administration		 intravenously
Legal status
Legal status
  •  ?
Pharmacokinetic data
Bioavailability 100%
Metabolism Hepatic
Biological half-life 60-80% in 72 hours
Excretion Renal
Identifiers
CAS Number 3778-73-2
ATC code L01AA06 (WHO)
PubChem CID 3690
DrugBank APRD00007
Synonyms 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Chemical data
Formula C7H15Cl2N2O2P
Molar mass 261.1[[Script error: No such module "String".]]
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Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.[1]

It is sometimes abbreviated "IFO".[2]

Uses

It is given as a treatment for a variety of cancers, including:

Administration

It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous.

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

References

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External links


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  1. ↑ Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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