Beclamide
| 191px | |
| Systematic (IUPAC) name | |
|---|---|
|
N-benzyl-3-chloropropanamide | |
| Clinical data | |
| Routes of administration | Oral |
| Identifiers | |
| CAS Number | 501-68-8 |
| ATC code | N03AX30 (WHO) |
| PubChem | CID 10391 |
| ChemSpider | 9962 |
| Chemical data | |
| Formula | C10H12ClNO |
| Molar mass | 197.661 g/mol[[Script error: No such module "String".]] |
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| (verify) | |
Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a propionate
It possesses anticonvulsant activity.[1]
Side effects
Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.
Administration and pharmacology
Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours. Beclamide is possibly metabolized to 3-Chloropropanoic acid in vivo,[citation needed] which binds to the GHB receptor.
Uses
It has been used as a sedative and as an anticonvulsant.
It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. It is no longer used as an AED.
Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.[2]
References
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<references />, or <references group="..." />- The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
- Beclamide (in French)
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