Terlipressin

Terlipressin
	File:Terlipressin.png
Systematic (IUPAC) name
	1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-N-(2-amino-2-oxoethyl)-L-lysinamide
Clinical data
Routes of; administration	IV
Pharmacokinetic data
Protein binding	~30%
Identifiers
CAS Number	14636-12-5
ATC code	H01BA04 (WHO)
PubChem	CID 72081
DrugBank	EXPT03310
Chemical data
Formula	C52H74N16O15S2
Molar mass	1227.37 g/mol[[Script error: No such module "String".]]

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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shock^[1] and hepatorenal syndrome.^[2] In addition, it is used in bleeding esophageal varices.^[3]

Terlipressin is marketed under the brand names Haemopressin (IS Pharmaceuticals), Variquel (IS Pharmaceuticals) or Glypressin (Ferring Pharmaceuticals).

Availability

Terlipressin is currently not available in the United States,^[4] or Canada.^[5]

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↑ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209–10. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542.
↑ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol. 33 (1): 43–8. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585.
↑ Ioannou G, Doust J, Rockey D (2003). "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev (1): CD002147. doi:10.1002/14651858.CD002147. PMID 12535432.
↑ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events".
↑ "Drug Product Search".