Cafestol
| 300px | |
| Systematic (IUPAC) name | |
|---|---|
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(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro- 7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol | |
| Clinical data | |
| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 469-83-0 |
| ATC code | none |
| PubChem | CID 108052 |
| ChemSpider | 10289419 |
| Chemical data | |
| Formula | C20H28O3 |
| Molar mass | 316.439 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| Physical data | |
| Melting point | 158 to 162 °C (316 to 324 °F) |
Cafestol is a diterpene molecule present in coffee.
A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee/Greek coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.
Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.[1]
Cafestol has also shown anticarcinogenic properties in rats. [1]
According to a 2007 study from Dr. David Moore's lab at Baylor College of Medicine[2], cafestol may act as an agonist ligand for the nuclear receptor Farnesoid X receptor and Pregnane X receptor, blocking cholesterol homeostasis.
Cafestol has also been implicated in inhibiting the progress of Parkinson's disease[3]
See also
References
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da:Cafestol de:Cafestol fr:Cafestol it:Cafestol
nl:Cafestol- ↑ 1.0 1.1 National Toxicology Program (NTP): Cafestol (CASRN 469-83-0) and Kahweol (CASRN 6894-43-5) - Review of Toxicological Literature. (PDF) October 1999
- ↑ The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
- ↑ http://www.newscientist.com/article/dn18814-parkinsons-protection-without-caffeine-or-nicotine.html New Scientist Article on Cafestol and it's potential role in helping prevent or delay Parkinson's disease
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