Stampidine
From Self-sufficiency
Revision as of 10:36, 11 September 2010 by حسن علي البط (Talk) (Adding category Category:Methyl esters (using HotCat))
| File:Stampidine.png | |
| Systematic (IUPAC) name | |
|---|---|
|
methyl N-((4-bromophenoxy){[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methoxy}phosphoryl)-D-alaninate | |
| Identifiers | |
| ATC code | none |
| PubChem | CID 469782 |
| Chemical data | |
| Formula | C20H23BrN3O8P |
| Molar mass | 544.289 g/mol[[Script error: No such module "String".]] |
Stampidine is an experimental nucleoside reverse transcriptase inhibitor (NRTI).
It is a derivative of d4T (stavudine, Zerit), and has been designed to avoid dependence on the rate limiting step of phosphorylation of stavudine to stavudine monophosphate. This is governed by the supply of thymidine kinase that is available, and stavudine is poorly phosphorylated to its monophosphate form in thymidine kinase-deficient cells. [1]
References
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