Fialuridine
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Revision as of 22:53, 10 September 2010 by حسن علي البط (Talk) (Removed Category:Pyrimidines; Adding category Category:Pyrimidinediones (using HotCat))
File:Fialuridine.png | |
Systematic (IUPAC) name | |
---|---|
1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)- 2-tetrahydrofuranyl]-5-iodopyrimidine-2,4-dione | |
Identifiers | |
ATC code | none |
PubChem | CID 50313 |
Synonyms | 2′-Fluoro-5-iodouracil |
Chemical data | |
Formula | C9H10FIN2O5 |
Molar mass | 372.09 g/mol[[Script error: No such module "String".]] |
Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue. It was originally designed as a therapy for hepatitis B virus infection. Unexpected toxicity lead to the death of 5 out of 15 patients in a clinical study at the NIH from fulminant liver failure. This toxicity was unusual in that it was not predicted by animal studies.
References
- McKenzie R, Fried MW, Sallie R; et al. (1995). "Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B". N. Engl. J. Med. 333 (17): 1099–105. doi:10.1056/NEJM199510263331702. PMID 7565947.
- Review of the Fialuridine (FIAU) Clinical Trials, Committee to Review the Fialuridine (FIAU/FIAC) Clinical Trials, Division of Health Sciences Policy INSTITUTE OF MEDICINE Frederick J. Manning and Morton Swartz, Editors NATIONAL ACADEMY PRESS Washington, D.C.1995
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