GPR37
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| G protein-coupled receptor 37 (endothelin receptor type B-like) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPR37; EDNRBL; PAELR; hET(B)R-LP | ||||||||||||
| External IDs | OMIM: 602583 MGI: 1313297 HomoloGene: 3875 IUPHAR: GPR37 GeneCards: GPR37 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2861 | 14763 | |||||||||||
| Ensembl | ENSG00000170775 | ENSMUSG00000039904 | |||||||||||
| UniProt | O15354 | Q9QY42 | |||||||||||
| RefSeq (mRNA) | NM_005302 | NM_010338 | |||||||||||
| RefSeq (protein) | NP_005293 | NP_034468 | |||||||||||
| Location (UCSC) | Chr 7: 124.17 - 124.19 Mb | Chr 6: 25.62 - 25.64 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.[1][2]
Interactions
GPR37 has been shown to interact with HSPA1A[3] and Parkin (ligase).[4][3]
References
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<references />, or <references group="..." />Further reading
- Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochem. Biophys. Res. Commun. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
- Donohue PJ, Shapira H, Mantey SA; et al. (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system". Brain Res. Mol. Brain Res. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.
- Imai Y, Soda M, Inoue H; et al. (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
- Imai Y, Soda M, Hatakeyama S; et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Yang Y, Nishimura I, Imai Y; et al. (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila". Neuron. 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.
- Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961 Freely accessible. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Imai Y, Soda M, Murakami T; et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Kubota K, Niinuma Y, Kaneko M; et al. (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". J. Neurochem. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
- Omura T, Kaneko M, Okuma Y; et al. (2007). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin". J. Neurochem. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
- ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
