GPR56
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| G protein-coupled receptor 56 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPR56; BFPP; DKFZp781L1398; TM7LN4; TM7XN1 | ||||||||||||
| External IDs | OMIM: 604110 MGI: 1340051 HomoloGene: 4156 IUPHAR: GPR56 GeneCards: GPR56 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9289 | 14766 | |||||||||||
| Ensembl | ENSG00000205336 | ENSMUSG00000031785 | |||||||||||
| UniProt | Q9Y653 | Q8K209 | |||||||||||
| RefSeq (mRNA) | NM_005682 | NM_018882 | |||||||||||
| RefSeq (protein) | NP_005673 | NP_061370 | |||||||||||
| Location (UCSC) | Chr 16: 56.24 - 56.26 Mb | Chr 8: 97.87 - 97.9 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
G-protein coupled receptor 56 is a protein that in humans is encoded by the GPR56 gene.[1][2][3]
In melanocytic cells GPR56 gene expression may be regulated by MITF[4].
References
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Further reading
- Xu L, Hynes RO (2007). "GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment". Cell Cycle. 6 (2): 160–5. PMID 17314516.
- Piao X, Basel-Vanagaite L, Straussberg R; et al. (2002). "An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21". Am. J. Hum. Genet. 70 (4): 1028–33. doi:10.1086/339552. PMC 379097 Freely accessible. PMID 11845408.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 Freely accessible. PMID 12975309.
- Little KD, Hemler ME, Stipp CS (2005). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association". Mol. Biol. Cell. 15 (5): 2375–87. doi:10.1091/mbc.E03-12-0886. PMC 404030 Freely accessible. PMID 15004227.
- Piao X, Hill RS, Bodell A; et al. (2004). "G protein-coupled receptor-dependent development of human frontal cortex". Science. 303 (5666): 2033–6. doi:10.1126/science.1092780. PMID 15044805.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 Freely accessible. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Shashidhar S, Lorente G, Nagavarapu U; et al. (2005). "GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion". Oncogene. 24 (10): 1673–82. doi:10.1038/sj.onc.1208395. PMID 15674329.
- Sud N, Sharma R, Ray R; et al. (2006). "Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma". Cancer Lett. 233 (2): 265–70. doi:10.1016/j.canlet.2005.03.018. PMID 15916848.
- Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Xu L, Begum S, Hearn JD, Hynes RO (2006). "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. doi:10.1073/pnas.0602681103. PMC 1474142 Freely accessible. PMID 16757564.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ "Entrez Gene: GPR56 G protein-coupled receptor 56".
- ↑ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
