17-Dimethylaminoethylamino-17-demethoxygeldanamycin
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| 17-Dimethylaminoethylamino-17-demethoxygeldanamycin | |
|---|---|
| File:17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.png | |
| [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-21-(2-dimethylaminoethylamino)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | |
| Other names 17-DMAG; Alvespimycin | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 467214-20-6 |
| PubChem | 5288674 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C32H48N4O8 |
| Molar mass | 616.75 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin.[1][2] It is being studied for the possibility of treating cancer.[3]
References
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- ↑ WO application 2002079167, Snader, Kenneth M.; Vishnuvajjala, B. Rao; Hollingshead, Melinda G.; Sausville, Edward A., "Preparation of geldanamycin derivatives for the treatment of cancer", published 2002
- ↑ Rastelli, Giulio; Tian, Zong-Qiang; Wang, Zhan; Myles, David; Liu, Yaoquan (2005). "Structure-based design of 7-carbamate analogs of geldanamycin". Bioorganic & Medicinal Chemistry Letters. 15 (22): 5016–5021.
- ↑ Sausville, E. A.; Tomaszewski, J. E.; Ivy, P. (2003). Curr. Cancer Drug Targets. 3: 377. Missing or empty
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