Scoulerine
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| Scoulerine | |
|---|---|
| Scoulerine | |
| (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino [3,2-a]isoquinoline-2,9-diol | |
| Other names Discretamine, Aequaline, Scoulerin. | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 605-34-5 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C19H21NO4 |
| Molar mass | 327.37 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Scoulerine, also known as discretamine and aequaline, is an alkaloid found in the Opium poppy[1], Croton flavens[2], and certain plants in the Erythrina genus[3]. Studies show that scoulerine is an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor[4][5]. It has also been found to be a GABAA receptor agonist[6][2].
References
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| 25px | This article about a heterocyclic compound is a stub. You can help ssf by expanding it. |
- ↑ Frick S, Chitty JA, Kramell R, Schmidt J, Allen RS, Larkin PJ, Kutchan TM. (2004). "Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots". Transgenic Res. 13 (6): 607–13. doi:10.1007/s11248-004-2892-6. PMID 15672841.
- ↑ 2.0 2.1 Eisenreich WJ, Hofner G, Bracher F. (2003). "Alkaloids from Croton flavens L. and their affinities to GABA-receptors". Nat Prod Res. 17 (6): 437–40. doi:10.1080/1478641031000111516. PMID 14577695.
- ↑ Ito K. (1999). "Studies on the alkaloids of Erythrina plants". Yakugaku Zasshi. 119 (5): 340–56. PMID 10375996.
- ↑ Ko FN, Yu SM, Su MJ, Wu YC, Teng CM. (1993). "Pharmacological activity of (-)-discretamine, a novel vascular alpha-adrenoceptor and 5-hydroxytryptamine receptor antagonist, isolated from Fissistigma glaucescens". Br J Pharmacol. 110 (2): 882–8. PMC 2175899 Freely accessible. PMID 7902181.
- ↑ Ko FN, Guh JH, Yu SM, Hou YS, Wu YC, Teng CM. (1994). "(-)-Discretamine, a selective alpha 1D-adrenoceptor antagonist, isolated from Fissistigma glaucescens". Br J Pharmacol. 112 (4): 1174–80. PMC 1910235 Freely accessible. PMID 7952879.
- ↑ Halbsguth C, Meissner O, Haberlein H. (2003). "Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site". Planta Med. 69 (4): 305–9. doi:10.1055/s-2003-38869. PMID 12709895.
