Poly(N-isopropylacrylamide)
Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAAm, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s.[1]
It forms a three-dimensional hydrogel when crosslinked with N,N’-methylene-bis-acrylamide (MBAm) or N,N’-cystamine-bis-acrylamide (CBAm). When heated in water above 33°C, it undergoes a reversible lower critical solution temperature phase transition from a swollen hydrated state to a shrunken dehydrated state, losing about 90% of its mass. Since PNIPAm expels its liquid contents at a temperature near that of the human body, PNIPAm has been investigated by many researchers for possible applications in controlled drug delivery.[2][3][4]
References
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- ↑ Schild, H. G. “Poly(N-isopropylacrylamide): experiment, theory and application” Progress in Polymer Science, 1992, 17 (2), 163–249.
- ↑ Chung, J. E.; Yokoyama, M.; Yamato, M.; Aoyagi, T.; Sakurai, Y.; Okano, T. “Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)” Journal of Controlled Release, 1999, 62, 115–127. Abstract
- ↑ Hu Yan and Kaoru Tsujii. “Potential application of poly(N-isopropylacrylamide) gel containing polymeric micelles to drug delivery systems” Colloids and Surfaces B: Biointerfaces. 2005, 46, 142–146. Abstract
- ↑ Antunes F. , Gentile L. , Tavano L. , Oliviero Rossi C. , " Rheological characterization of the thermal gelation of poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide)co-Acrylic Acid". Applied Rheology, 2009, Vol. 19, n. 4, pp. 42064-42069. Abstract
