Chlorzoxazone
From Self-sufficiency
| File:Chlorzoxazone.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
5-chloro-3H-benzooxazol-2-one | |
| Clinical data | |
| Routes of administration | oral |
| Pharmacokinetic data | |
| Bioavailability | well absorbed |
| Protein binding | 13–18% |
| Metabolism | hepatic |
| Biological half-life | 1.1 hr |
| Excretion | urine (<1%) |
| Identifiers | |
| CAS Number | 95-25-0 |
| ATC code | M03BB03 (WHO) |
| PubChem | CID 2733 |
| DrugBank | APRD00308 |
| ChemSpider | 2632 |
| Chemical data | |
| Formula | C7H4ClNO2 |
| Molar mass | 169.565 g/mol[[Script error: No such module "String".]] |
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| (verify) | |
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Muscol or Parafon Forte, a combination of chlorzoxazone and acetaminophen (Paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended. For a more in depth look at Chlorzoxazone visit http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=15262.
External links
- Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta". Eur J Pharmacol. 545 (2-3): 161. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676.
- Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe". J Clin Pharmacol. 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290.
- Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats". J Pharm Pharmacol. 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMC 1388188 Freely accessible. PMID 16393464.
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