Coronary reflex
From Self-sufficiency
Coronary reflex is the change of coronary diameter in response to chemical, neurological or mechanical stimulation of the coronary arteries.
The coronary reflex are stimulated differently than the rest of the vascular system.
Contents
Causes of coronary constriction
Chemical
- N-nitro L-arginine
- indomethacin
- glibenclamide
- tetraethylammonium chloride
- caffine
Other
- Cold
Causes of coronary dilation
Cocaine abuse frequently can cause a coronary spasm, resulting in a spontaneous myocardial infarction.
Chemical
- Versed (Midazolam): a coronary dilator. In midazolam's presence, dilation was unaffected by N-nitro L-arginine, indomethacin and glibenclamide.
- Tetraethylammonium chloride, an inhibitor of the BKCa K+ channel (a high conductance Ca2+-sensitive K+ channel), dose dependently attenuated the vasodilating effect of midazolam [1]
- Estrogen has been shown to abolish abnormal cold-induced coronary constriction.[2]
References
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<references />, or <references group="..." />- ↑ O.L. Woodman; G.J. Dusting (1991). "N-nitro L-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds". Br. J. Pharmacol. 103 (2): 1407–1410. PMC 1908370 Freely accessible. PMID 1909199.
- ↑ Steven E. Reis, MD; Richard Holubkov, PhD; Kathleen A. Zell, BSN; AJ. Conrad Smith, MD; Howard A. Cohen, MD; Marc D. Feldman, MD; and Roger S. Blumenthal, MD (1998). "Estrogen Acutely Abolishes Abnormal Cold-Induced Coronary Constriction in Men*". CHEST. 114 (6): 1556–1561. doi:10.1378/chest.114.6.1556. PMID 9872188.
