Template:PBB/351

Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
250px PDB rendering based on 1aap.
Available structures PDB 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1brc, 1ca0, 1iyt, 1mwp, 1owt, 1rw6, 1taw, 1tkn, 1z0q, 1zjd, 2beg, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47
Identifiers
Symbols	APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2
External IDs	OMIM: 104760 MGI: 88059 HomoloGene: 56379 GeneCards: APP Gene
Gene Ontology Molecular function • DNA binding • serine-type endopeptidase inhibitor activity • binding • iron ion binding • copper ion binding • heparin binding • zinc ion binding • identical protein binding • metal ion binding Cellular component • extracellular region • membrane fraction • cytoplasm • Golgi apparatus • integral to plasma membrane • coated pit • cell surface • membrane • integral to membrane • axon • cytoplasmic vesicle • neuromuscular junction • ciliary rootlet • apical part of cell • perinuclear region of cytoplasm • spindle midzone Biological process • G2 phase of mitotic cell cycle • suckling behavior • mRNA polyadenylation • cellular copper ion homeostasis • endocytosis • apoptosis • cell adhesion • Notch signaling pathway • axonogenesis • mating behavior • axon cargo transport • adult locomotory behavior • visual learning • axon midline choice point recognition • neuron remodeling • dendrite development • extracellular matrix organization and biogenesis • forebrain development • regulation of body size • positive regulation of progression through mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • collateral sprouting in the absence of injury • regulation of synapse structure and activity • regulation of balance • neuromuscular process • synaptic growth at neuromuscular junction • smooth endoplasmic reticulum calcium ion homeostasis Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	351	11820
Ensembl	ENSG00000142192	ENSMUSG00000022892
UniProt	P05067	Q8BPC7
RefSeq (mRNA)	NM_000484	NM_007471
RefSeq (protein)	NP_000475	NP_031497
Location (UCSC)	Chr 21: 26.17 - 26.47 Mb	Chr 16: 84.84 - 85.06 Mb
PubMed search	[1]	[2]