5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole

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5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
File:Dichlororibofuranosylbenzimidazole.png
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 53-85-0
PubChem 5894
ChemSpider 5683
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InChI key XHSQDZXAVJRBMX-DDHJBXDOBF
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C12H12Cl2N2O4
Molar mass 319.14 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.[1]

References

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