7-Hydroxymitragynine

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7-Hydroxymitragynine
7-Hydroxymitragynine
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C23H30N2O5
Molar mass 414.49 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

7-Hydroxymitragynine, an indole, is an active alkaloid in the plant Mitragyna speciosa, commonly known as Kratom. It has opioid agonistic activity.[1] "The potency, calculated using pD (2) values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine."[2]

7-Hydroxymitragynine is orally active in animals as an analgesic,[3] and produces normal opioid side effects including constipation[4] development of tolerance and withdrawal syndrome upon abstinence.[3] The O-acetyl ester, 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist.[5]

See also

References

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