BSPP (drug)

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BSPP (drug)
File:BSPP structure.png
Systematic (IUPAC) name
2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol
Identifiers
ATC code none
PubChem CID 16079861
Chemical data
Formula C21H34O2
Molar mass 318.492 g/mol[[Script error: No such module "String".]]
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BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It has a synergistic effect with GABAB agonists such as baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]

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References

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  1. ↑ Kerr DIB, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M. Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols. Australian Journal of Chemistry. 2006;59:457-462.
  2. ↑ Parker DA, Marino V, Ong J, Puspawati NM, Prager RH. The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors. Clinical and Experimental Pharmacology and Physiology. 2008 Sep;35(9):1113-5. PMID 18430050
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