Balsalazide
From Self-sufficiency
| File:Balsalazide.png | |
| Systematic (IUPAC) name | |
|---|---|
|
(E)-5-([4-(2-carboxyethylcarbamoyl)phenyl]diazenyl)-2-hydroxybenzoic acid | |
| Clinical data | |
| Pregnancy category |
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| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | <1% |
| Protein binding | ≥99% |
| Biological half-life | 12hr |
| Identifiers | |
| CAS Number | 80573-04-2 |
| ATC code | A07EC04 (WHO) |
| PubChem | CID 5362070 |
| DrugBank | APRD00141 |
| ChemSpider | 10662422 |
| Chemical data | |
| Formula | C17H15N3O6 |
| Molar mass | 357.318 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| (verify) | |
Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK. It is also sold in generic form in the US by several generic manufacturers.
It is usually administered as the disodium salt.
Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA,[1] in the large intestine. Its advantage over that drug in the treatment of ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.
References
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<references />, or <references group="..." />- ↑ Kruis, W; Schreiber, I; Theuer; Brandes; Schütz; Howaldt; Krakamp; Hämling; Mönnikes (2001). "Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses". Gut. 49 (6): 783–9. doi:10.1136/gut.49.6.783. PMC 1728533 Freely accessible. PMID 11709512. More than one of
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