Benzylmorphine

Benzylmorphine

160px
160px
Systematic (IUPAC) name
(1S,5R,13R,14S,17R)- 10-(benzyloxy)- 4-methyl- 12-oxa- 4-azapentacyclo [9.6.1.01,13.05,17.07,18] octadeca- 7(18),8,10,15- tetraen- 14-ol
Legal status
Legal status	US: Schedule I
Identifiers
CAS Number	14297-87-1
ATC code	none
PubChem	CID 5362507
ChemSpider	4515062
Synonyms	Benzylmorphine, Peronine, 3-Benzyloxy- 4,5α-epoxy- 17-methyl- 7-morphinen-6α-ol
Chemical data
Formula	C24H25NO3
Molar mass	375.46 g/mol[[]]
(verify)

Benzylmorphine (Peronine) is a semi-synthetic opiate narcotic introduced to the international market in 1896 and that of the United States very shortly thereafter. It is much like codeine, containing a benzyl group attached to the morphine molecule just as the methyl group creates codeine and the ethyl group creates ethylmorphine or dionine (used as a generic name for that drug just as peronine is for benzylmorphine). It is about 90 per cent as strong as codeine by weight.

Benzylmorphine is used in much the same way as codeine and ethylmorphine, primarily as a moderate strength analgesic, for eye surgery as a 1 to 2 per cent solution, and as a cough suppressant. It was available in the United States prior to 1914 and was still used until the 1960s, but fell into disuse once alternative opiate derivatives became preferred by doctors (i.e. hydrocodone as an analgesic and codeine as a cough suppressant) Benzylmorphine is now a Schedule I Controlled Substance in the USA and is regulated internationally under UN drug conventions.

Benzylmorphine is an active metabolite of the opioid analgesic myrophine, formed in the liver. It has a metabolic fate similar to that of codeine.

Benzylmorphine is used as the hydrochloride (free base conversion ratio 0.91) and methylsulphonate(0.80) and has a US DEA Administrative Controlled Substance Control Number of 9052.

References

• Merck Manual, 1900
• Merck Index, 1998
• United States Department of Justice, Drug Enforcement Administration: Controlled Substances in Schedule I

ru:Бензилморфин