Chlorphenesin

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Chlorphenesin
File:Chlorphenesin.png
Systematic (IUPAC) name
(3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate
Pharmacokinetic data
Excretion urine
Identifiers
CAS Number 886-74-8
ATC code D01AE07 (WHO)
PubChem CID 2724
ChemSpider 2623
Chemical data
Formula C10H12ClNO4
Molar mass 245.660 g/mol[[Script error: No such module "String".]]
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Physical data
Melting point 86 to 92 °C (187 to 198 °F)
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Chlorphenesin (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.[1][2]

It also has antifungal and some antibacterial properties and is thus classified as an antifungal for topical use by the WHO.[3]

Safety

The adverse effects from this preservative on skin is allergic contact sensitivity.[4][5]

Physical Properties

Melting Point

86-92 deg. Celsius[6]

References

  1. ↑ Okuyama S, Aihara H. Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats. Research Communications in Chemical Pathology and Pharmacology. 1987 Feb;55(2):147-60. PMID 3823606
  2. ↑ Kurachi M, Aihara H. Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Japanese Journal of Pharmacology. 1984 Sep;36(1):7-13. PMID 6503049
  3. ↑ ATC code D01AE07
  4. ↑ Brown R (1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. 
  5. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  6. ↑ Salim, E.F.; Booth, R.E. (1967). "Qualitative and quantitative tests for chlorphenesin carbamate". Journal of Pharmaceutical Sciences. 56 (5): 623. doi:10.1002/jps.2600560516. Retrieved 2009-06-23. 
Wall/
membrane
Ergosterol
inhibitors
topical: Thiabendazole
topical: (Natamycin, Nystatin#)
systemic: (Amphotericin B#)
Intracellular
Others

M: MYC

drug (fung)

Peripherally acting
(primarily antinicotinic,
Neuromuscular junction block)
Tertiary amines / Non-curare alkaloids
ultra-short duration: Gantacurium

short duration: Mivacurium  · Chandonium

intermediate duration: Atracurium  · Cisatracurium  · Fazadinium  · Rocuronium  · Vecuronium  · Dipyrandium  · N,N'-Dimethylconessine  · Stercuronium  · Dacuronium  · Mytolon

long duration: Doxacurium · Dimethyltubocurarine · Pancuronium · Pipecuronium  · Laudexium  · Gallamine  · Benzoquinonium  · Decaethonium  · Succinyl-bis-β-phenylcholine  · Anatruxonium  · Truxilonium  · Cyclobutonium  · Dipyronium · Pyrocurinum  · Tercuronium  · Diadonium

unsorted: Hexafluronium (Hexafluorenium)  · Myanesin  · Cyclobutonium  · Mebutanium  · Amidonium  · Nubitanium  · Quilidium  · Decadonium
Clostridium botulinum toxin  · Atraxotoxin  · β-Bungarotoxin  · Black widow spider venom
Centrally acting
Other
Directly acting

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)


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pt:Clorfenesina
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