Ciclazindol

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Ciclazindol
File:Ciclazindol.png
Systematic (IUPAC) name
10-(3-chlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]indol-10-ol
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  •  ?
Pharmacokinetic data
Metabolism Renal[1]
Biological half-life ~32 hours[1]
Excretion Urine, Feces[1]
Identifiers
CAS Number 37751-39-6
PubChem CID 37825
ChemSpider 34683
Chemical data
Formula C17H15ClN2O
Molar mass 298.77 g/mol
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Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed.[2][3] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.[2][4] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor.[4][5][6] As suggested by its local anesthetic properties,[5] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[7][8]

See also

References

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  3. Levine S (1979). "A controlled comparative trial of a new antidepressant, ciclazindol". The Journal of International Medical Research. 7 (1): 1–6. PMID 369921. 
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