Clofedanol

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Clofedanol
File:Clofedanol.svg
Systematic (IUPAC) name
1-(2-chlorophenyl)-3-dimethylamino-
1-phenyl-propan-1-ol
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 791-35-5
ATC code R05DB10 (WHO)
PubChem CID 2795
ChemSpider 2693
Chemical data
Formula C17H20ClNO
Molar mass 289.8 g/mol[[Script error: No such module "String".]]
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Clofedanol (INN) or chlophedianol (BAN) is a centrally-acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009[2]. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[3] and its safety and efficacy data are limited.

References

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Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
Other

M: RES

anat(n, x, l, c)/phys/devp

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fr:Chlophédianol
  1. ↑ (French) "Clofedanol". BIAM. 1998-07-24. Retrieved 2007-04-15. 
  2. ↑ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27. 
  3. ↑ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12. 
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