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DS-1 (drug) - Revision history
2024-03-28T16:02:46Z
Revision history for this page on the wiki
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Jontas: 1 revision
2010-09-20T09:26:27Z
<p>1 revision</p>
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http://ssf.f15ijp.com/wiki/index.php?title=DS-1_(drug)&diff=32632&oldid=prev
حسن علي البط: Adding category :Category:Benzamides (using HotCat)
2010-09-19T13:26:18Z
<p>Adding category <a href="/wiki/index.php?title=Category:Benzamides&action=edit&redlink=1" class="new" title="Category:Benzamides (page does not exist)">Category:Benzamides</a> (using <a href="/wiki/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT (page does not exist)">HotCat</a>)</p>
<p><b>New page</b></p><div>{{drugbox<br />
| IUPAC_name = 4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide<br />
| image = DS-1_structure.png<br />
| CAS_number = 372497-52-4<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 979735<br />
| DrugBank = <br />
| C=18|H=10|Br=2|Cl=1|N=3|O=1|S=1<br />
| molecular_weight = 511.617 g/mol<br />
| smiles = s4cccc4-c2nc1c(Br)cc(Br)cn1c2NC(=O)c(cc3)ccc3Cl<br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life =<br />
| excretion = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category= <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = <br />
| routes_of_administration = <br />
}}<br />
<br />
'''DS-1''' is a drug from the [[imidazopyridine]] family which is the first drug developed that acts as a [[GABAA receptor|GABA<sub>A</sub>]] [[Receptor (biochemistry)|receptor]] [[agonist]] selective for the [[GABRA4|α4]][[GABRB3|β3]][[GABRD|δ]] subtype, which is not targeted by other GABA agonists such as the [[benzodiazepine]]s or other [[nonbenzodiazepine]] drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.<ref>Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. ''Neuropharmacology''. 2009 Jan;56(1):182-9. PMID 18762200</ref><br />
<br />
{{pharm-stub}}<br />
<br />
==See also==<br />
* [[Zolpidem]]<br />
* [[Alpidem]]<br />
* [[Saripidem]]<br />
<br />
== References ==<br />
{{reflist}}<br />
<br />
<br />
{{GABAergics}}<br />
<br />
[[Category:Imidazopyridines]]<br />
[[Category:Organobromides]]<br />
[[Category:Organochlorides]]<br />
[[Category:Thiophenes]]<br />
[[Category:Benzamides]]<br />
[[Category:2Fix]]</div>
حسن علي البط