DS-1 (drug)

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DS-1 (drug)
File:DS-1 structure.png
Systematic (IUPAC) name
CAS Number 372497-52-4
PubChem CID 979735
Chemical data
Formula C18H10Br2ClN3OS
Molar mass 511.617 g/mol[[Script error: No such module "String".]]
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DS-1 is a drug from the imidazopyridine family which is the first drug developed that acts as a GABAA receptor agonist selective for the α4β3δ subtype, which is not targeted by other GABA agonists such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.[1]

See also


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  1. Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 2009 Jan;56(1):182-9. PMID 18762200