Diethylthiambutene

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Diethylthiambutene
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Systematic (IUPAC) name
N,N-diethyl-4,4-dithiophen-2-yl-but-3-en-2-amine
Legal status
Legal status
Identifiers
CAS Number 86-14-6
ATC code none
PubChem CID 149833
Chemical data
Formula C16H21NS2
Molar mass 291.477 g/mol[[Script error: No such module "String".]]
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Physical data
Melting point 152 to 153 °C (306 to 307 °F)
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Diethylthiambutene (Thiambutene, Themalon, Diethibutin, N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine) is an opioid analgesic drug developed in the 1950s[1] which was mainly used as an anesthetic in veterinary medicine and continues, along with the other two thiambutenes dimethylthiambutene and ethylmethylthiambutene to be used for this purpose, particularly in Japan.[2][3] It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.

References

  1. BECKETT AH, CASY AF, HARPER NJ, PHILLIPS PM. Analgesics and their antagonists: some steric and chemical considerations. II. The influence of the basic group on physico-chemical properties and the activity of methadone and thiambutene-type compounds. Journal of Pharmacy and Pharmacology. 1956 Nov;8(11):860-73.
  2. Hayes MJ. The use of thiambutene hydrochloride. The Veterinary Record. 1968 Nov 16;83(20):528.
  3. Harbison WD, Slocombe RF, Watts SJ, Stewart GA. Thiambutene and acepromazine as analgesic and preanaesthetic agents in horses and sheep. Australian Veterinary Journal. 1974 Dec;50(12):543-6.
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